This tool allows you to annotate your variants and determine the effect on relevant Ensembl transcripts and proteins. You can input coordinates of any alleles you have identified or variant identifiers. A full list of input files is available. If a variant that you enter as input causes a change in the protein sequence, the VEP will calculate the possible amino acids at that position and the variant would be given a consequence type of missense. Have a look at other calculated variant consequences. VEP can be accessed through our online tool, available for bacteria, protists, fungi, plants and invertebrate metazoa; our script; or through the REST API.